top of page
시험관

Our Technology

At Dalton, we use our LC-MS-based to one-shot multi-omics platform to profile proteins, lipids, electrolytes, metabolites, drugs, and environmental chemicals in a single sample.

Mass Spectrometry

How We Are Different

conventional-omics VS Omni-MS

Traditional multiomics requires the integration of analytical results from multiple laboratories and technologies, introducing more cost and complexity to the process. Multi Omic studies are often ad hoc.

Dalton uses a proprietary one-shot assay to prepare and analyze all analytes with a single procedure, reducing cost and complexity, and maintaining data integrity.

Multiomics Using Omni-MS®

Omni-MS workflow

We use a combination of advanced enzymatic and chemical techniques at various steps of our process to enable the concurrent analysis of diverse analyte classes. For example, EDTA enables detection of metal-chelates, endolytic enzymes enable detection of oligomers, etc.

Example Study

Biomarker signatures in human plasma: examples in aging and inflammation

analytical plots

Using Omni-MS® we generated multi-omic data for plasma samples from small numbers of human donors. Here we briefly describe multi-omic association studies of chronological age (n = 170) and inflammation (n = 30) adjusting for technical covariates.

We find significant associations with numerous analytes that are distributed across the different biochemical classes including small molecules, lipids and proteins (Bonferroni p < 5x10-6; see Manhattan plots below). Importantly, we demonstrate this using small samples sizes demonstrating the high signal-to-noise of our assay.

Our Customers

merck
UCLA
Upside Foods
20Bloc
Harvard
Omniox
Enviroflight
University of Kentucky
FDA
Boston Medical Center
Gordian
Agrigro
nutreco
Pavir
Western University
Lawrence Livermore National Laboratory
bottom of page