The failing heart runs low on fuel well before symptoms force a diagnosis, yet routine cardiology almost never measures that fuel directly. A serum metabolomics study of 210 patients set out to map the shortfall across the ACC/AHA stages of heart failure. Xiao Zhang and colleagues paired untargeted screening with a targeted energy-metabolite panel, then asked which molecules track the slide from at-risk Stage A to symptomatic Stage C. Their answer points straight at the cell'

Endometriosis often takes years to confirm, and many women cycle through repeat imaging and laparoscopy before anyone names it. A reliable blood test would shorten that path, so the field keeps hunting for serum signals. A new BMC Medicine study put NMR-based metabolomics to a harder test than usual. Instead of comparing patients only against healthy donors, a Tübingen-led team asked whether a serum metabolite and lipoprotein panel could separate surgically confirmed endometr