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Spatial Metabolomics Mass Spectrometry Imaging: MALDI vs DESI forHigh-Resolution Tissue Mapping

Oct 13, 2025
0 min read
Infographic comparing MALDI and DESI mass spectrometry imaging for spatial metabolomics: MALDI uses matrix-coated cryosections and laser ionization for high spatial resolution but matrix clusters limit m/z < 500; DESI sprays charged solvent without matrix, allows section re-analysis, detects small metabolites, and both generate spectra and ion images for spatial lipidomics and drug mapping.

 
 
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