Genetic cardiomyopathy can hide in plain sight. A carrier of the phospholamban (PLN) p.Arg14del variant, written R14del, may look healthy on an echocardiogram for years, then slide into end-stage heart failure with little warning. Clinical proteomics offers a way to read that hidden trajectory from a single tube of plasma. A study in Cardiovascular Research profiled 87 R14del carriers across the disease spectrum, pairing targeted plasma proteomics with metabolomics and lipido

Low-dose CT scans pick up lung nodules that mostly turn out to be benign, and the false alarms drive biopsies, anxiety, and cost. A blood test that flags real malignancy would help decide who needs follow-up and who can be reassured. This is where proteomics earns its place. A group from Oxford Cancer Analytics and academic partners measured plasma proteins in 490 lung cancer patients and 124 matched controls, then used explainable machine learning to pull out a protein signa

Immune checkpoint blockade rescues only a sliver of colorectal cancer patients, the roughly 15 percent whose tumors are microsatellite instability-high or mismatch-repair-deficient. The microsatellite-stable majority mostly resists. A study in Molecular Therapy: Nucleic Acids applied multi-omics integration to the TCGA colorectal adenocarcinoma cohort to test whether that binary overlooks immune-hot tumors hiding inside the stable group. Pulling together messenger RNA, long n

HbA1c misleads more often than most clinicians like to admit. Iron deficiency, hemoglobinopathies, and high triglycerides all distort it, so the patient whose kidneys are quietly failing can slip past a single lab value. A recent biomarker discovery study in Frontiers in Endocrinology went hunting for a blood signal that warns earlier, mining plasma proteomics and metabolomics from 50,021 UK Biobank participants to find markers that flag type 2 diabetes complications years be

Depression travels with colorectal cancer far more often than chance would predict, yet separating cause from consequence has been hard, since a cancer diagnosis itself can drag mood down. A 2026 iScience study used multi-omics integration to break that loop, pairing plasma protein quantitative trait loci with genome-wide association data for colorectal precancer and cancer. Across a 2,857-patient colonoscopy cohort and 37,597 NHANES participants, the team chased the depressi