Diabetic heart failure remains a leading cause of cardiovascular death, yet the precise lipid species that push the diabetic myocardium toward dysfunction have stayed elusive. A 2026 study in Cardiovascular Diabetology: Endocrinology Reports applied multi-omics integration to human heart tissue, pairing untargeted lipidomics, metabolomics, and quantitative proteomics from the same myocardial samples. The authors uncovered what they call electrostatic lipidopathy, a charge-dep